You won't be disconnected from the world unless you want to be. N-NW of Knoxville is Oak Ridge, the home of the nuclear labs used by the US in WWII, and still the highest IQ per capita due to all the scientists out there. And just down the road is Knoxville, with the Tennessee Vols, if you are into rabid football fans. After all, how many cities with only 400,000 area residents manage to fill a 107,000 seat stadium for every home game? if you're not into football, game time is perfect for finding a seat in a local restaurant, as long as it's before they let out the stadium! And just a few miles more and you can find people that still need a flashlight and shoes to go to the bathroom after dark!
My wife and I still miss it up there, but the pressures of family and job opportunities brought us back to Houston. We still keep in contact with some up there, and may retire up there ourselves someday.