Krash, you can drive down I5 to patterson, than take del puerte canyon road to the junction west to hwy 130, about 20 miles, on a weekday you will see maybe one car.
at the junction of del puerte and mines road (hwy 130) is this great little bar and grill.
from there you can go north on 130 to livermore, about 60 miles, might see two cars on a weekday, are flats you can run the car at 120 no problem, just need to keep an eye out for wild pigs and tule elk.
Or you can go south back to san jose over mt Hamilton, about 40 miles, great drive
do NOT bring anyone along prone to getting carsick.